ginsenoside Rg5
| Name | Ginsenoside Rg5 | ||
| PubChem CID | 11550001 | ||
| Molecular Weight | 767.0g/mol | ||
| Synonyms |
ginsenoside Rg5 |
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| Formula | C₄₂H₇₀O₁₂ | ||
| SMILES | CC(=CCC=C(C)C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)C | ||
| InChI | 1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10-11,23-38,43-50H,9,12-20H2,1-8H3/b22-11+/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1 | ||
| InChIKey | NJUXRKMKOFXMRX-RNCAKNGISA-N | ||
| CAS Number | 186763-78-0 | ||
| ChEMBL ID | CHEMBL400244 | ||
| ChEBI ID | CHEBI:67992 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | RenShenLu | ||
| Use Part | Rhizome | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet, Mildly bitter | ||
| Meridian Tropism | Stomach, Spleen, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Chineses Pinyin | RenShen | ||
| Use Part | Root | ||
| Habitat | JiLin, LiaoNing, HeiLongJiang | ||
| Flavor | Sweet; Slightly Bitter | ||
| Meridian Tropism | Spleen; Lung; Heart; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Araliaceae
-->Genus: Panax
-->Species: Panax ginseng
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| Pair Name | Ginsenoside Rg5, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C77.Z] | Cervical cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAK1 | hsa578 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | BID | hsa637 | |
| Up-regulation | Expression | BBC3 | hsa27113 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | BIRC3 | hsa330 | |
| Down-regulation | Expression | MCL1 | hsa4170 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| In Vitro Model | HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 |
| HeLa/PTX | Papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_HF87 | |
| Result | Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel | |||
